Download The Microbiome Solution: A Radical New Way to Heal Your Body from the Inside Out pdf 厎 Ebook By Dr Robynne Chutkan M.D. ᓱ AcknowledgmentsIntroduction Live Dirty, Eat CleanMY HUSBAND ISNT completely on board with my plan to sell our house in the city, move to a farm, raise animals, and grow our own food But since much of whats available in the supermarket is full of chemicals and devoid of any real nutrients, taking control of what we eat and making sure it comes from nature, not a factory, strikes me as a good idea Im fortunate to live in Washington, D.C., where farmers markets and community supported agriculture CSA shares are plentiful, so moving to an actual farm may seem a little extreme My real motivation is that I want my daughter to grow up dirty, literallyas in easy on the soap and shampoo, heavy on the mucky animal chores I shared her saga of antibiotic misadventure in my first book, Gutbliss Since then, Ive seen hundreds of patients with stories similar to hers, and Ive become even convinced that damage to the microbiomethe trillions of organisms that call our digestive tract homeis at the root of many of our current health problems Figuring out how to undo that damage and rewild ourselves has become a focus of my medical practice and a personal journey in our household Living a little dirtier and eating a little cleaner is definitely part of the fix.Unwilding OurselvesOur ancestors had a symbiotic relationship with their microbes that evolved over millions of years and served them well They were benevolent hosts to a dense jungle of microscopic creatures, including worms and other parasites that actually contributed to their health Large predators and the absence of food were their main threats, not the hundreds of diseases that afflict us today The irony is that as weve unwilded our bodies and our environment in an effort to become healthier, weve actually become a lot sicker in some important ways.Urbanization and modern medicine have undoubtedly improved our lives, but theyve also introduced practicesoveruse of antibiotics, chlorination of the water supply, processed foods full of chemicals and hormones, microbe depleting pesticides, increasing rates of Cesarean sectionsthat have ravaged our microbiome, diminishing the total number of organisms as well as the diversity of species The result is an increase in a wide range of modern plagues, including asthma, allergies, autoimmune diseases, diabetes, obesity, cancer, irritable bowel syndrome, anxiety, and heart disease The rise of these diseases is inextricably intertwined with the full on assault on our microbiome resulting from our super sanitized lifestyle.A decade ago, who knew that every antibiotic dispensed during cold and flu season was potentially bringing us one step closer to a diagnosis of Crohns disease, or making us fatter None of us doing the prescribing realized that we might be paving the way to real illness in our well meaning attempts to cure the sniffles The prevailing wisdom wasand to some extent still isthat germs are bad and we should get rid of them, and antibiotics are good and we should use them And use them we have the average American child will receive than a dozen courses of antibiotics before reaching college, primarily for minor illnesses that require no treatment at all Despite the tremendous amount of research in the last few years connecting the dots, many physicians and their patients remain in the dark, blaming each manifestation of microbial discord on bad luck or bad genes, never questioning or understanding the root cause.Less Is Often MoreMy own understanding came only after my daughter was treated with antibiotics at birth and throughout infancy, setting off a series of events that, a decade later, continue to affect her health I had been trained at world class institutions and practiced gastroenterology at a leading teaching hospital, but, like most physicians, I had no idea that the antibiotics I thought were so helpful were actually creating illness by decimating her microbiome at a time when it was most vulnerable, making her susceptible to infection and inflammation I wish I had known then what I know now and what I continue to learn every day that illness is often the result of a decreased, not increased, bacterial load, and that less is sometimes when it comes to medical intervention.Rehab for Your MicrobiomeEvery day in my gastroenterology practice I see patients with the telltale signs of a disordered microbiome bloating, leaky gut, irritable bowel, gluten intolerance, Crohns disease, ulcerative colitis, eczema, thyroid disorders, weight problems, fatigue, and brain fog Its a veritable epidemic of missing microbes, as infectious disease specialist Martin Blaser, MD, describes it The symptoms vary, but the history doesnt overzealous use of antibiotics, often accompanied by a highly processed Western diet low in indigestible plant fiberthe preferred food of gut bacteria.Repopulating the microbiome can be a challenging process, but the good news is that most people do get better Your microbes are constantly changing and evolving, and even if theyve been severely damaged by medications, infection, or diet, paying attention to what you put in and on your body can yield huge improvements The microbiome you have today isnt the one you were born with, nor is it the one youll have next year or even next week Its highly dynamic, constantly changing and adjusting in response to your internal and external environment.In medical school, I was taught how to eradicate peoples germs A quarter century later, Im teaching my patients how to restore theirs which foods to eat, how to care for their bodies and their homes without stripping away their microbes, what questions to ask when their doctor recommends an antibiotic, and whether a probiotic or even a stool transplant might be of benefit These, I believe, are the new and essential survival skills for thriving in our super clean era Youll find them all in the Live Dirty, Eat Clean Plan at the end of this book.When Dirty Children Grow into Clean AdultsMy Rewilding JourneyI spent my early childhood in the tropics, eating food from my grandfathers farm grown in rich soil fertilized by a herd of goats which we sometimes also ate instead of chemicals We lived in the hilly suburbs and roamed around outside with our dog after school, exploring gullies, picking mangoes and oranges from the fruit trees in our backyard, and acquiring the occasional case of pinworm as a result of our barefoot explorations In our household there was lots of attention paid to schoolwork and athletics, but shoes, showers, and shampoos were or less optional My father was an orthopedic surgeon whose great fear was that his children would grow up to be hypochondriacs, so his medical advice for whatever ailed usfrom the flu to a sprained anklewas always the same go lie down and youll feel better in the morning We were vaccinated for the big stuff polio and smallpox but didnt sweat the small stuff whooping cough and chicken pox My daughter had visits to the doctor before she was in preschool than Ive had in my entire lifetime.So, despite my dirty childhood filled with organic, homegrown food, protective parasites, lots of time outdoors, and limited contact with an overzealous medical system, how did I end up in adulthood with not one but three manifestations of microbial discord eczema, rosacea, and yeast overgrowth It took a while I managed to weather potent microbial disruptors like the antibiotics prescribed in college for acne and twenty years of birth control pills well talk about this in Chapter 5 with no ill effects But as life got complicated, unrelenting stress and the cookies, cakes, and candy I consumed to combat it were my ultimate undoing A Western diet high in sugar and fat promotes growth of the wrong types of bacteria in your gut, and a lifestyle that leaves literally no time to go outside and smell the roses can be the straw that breaks the camels back, particularly if you have additional risk factors, as I did, such as significant antibiotic use.Disease Begins in Your MicrobiomeMy firsthand experience with how poor nutrition and stress can unmask the effects of a damaged microbiome and lead to a multitude of symptoms is representative of what most of the patients I see in my office have experienced a decline in overall well being characterized by seemingly unrelated conditions that appear out of nowhere, leaving them scratching their head and wondering whats going on.Microbial disruptors are everywherein the food we eat, the water we drink, the products we use, and the medications we takeand the clinical manifestations of a disrupted microbiome are varied and show up in people of all ages and stages Chances are theres someone in your family with asthma, allergies, eczema, thyroiditis, diabetes, arthritis, or any of the many disorders that were now discovering have the same root cause A damaged microbiome isnt the only reason people develop these conditions, but its often a major contributor that interacts with genetic and environmental factors to create a perfect storm of disease Thats why its important than ever to understand the complex and critical role bacteria play in our health, so that if and when yours is compromised, you can connect the dots and start to heal yourself.The solutions youll find in this book are based on clinical trials in our own patient population at the Digestive Center for Women, data from other scientific studies, published papers, trial and error, anecdote, patient testimonials about whats worked for them, and careful observations accrued over almost two decades of taking care of people with all kinds of bacterial imbalancefrom serious autoimmune illnesses such as Crohns disease and ulcerative colitis to complaints of gas and bloating Theyre also based on my own journey of exploration and healing necessitated by my health challenges.The new paradigm of bacteria as friend rather than foe is at the heart of a revolution in health care thats forcing us to reexamine how we live, as well as our medical practices, with new microscopic eyes, and to consider how modern life and our everyday choices affect the life of our microbesand how our microbes in turn affect us What has become very clear is that our individual and collective health depends on it My sincere hope is that this book will provide you with the microbiome solution that will help you reclaim your health and vitality and set you on the path to a dirtier and disease free life.See you on the farm part 1CHAPTER 1 OUR MICROBES ARE intimately involved in every aspect of our healthfrom ensuring our digestive well being to influencing our likelihood of being obese and our risk of developing cancer or diabetes They even play a role in our brain chemistry and mental health, affecting our moods, our emotions, and our personalities We are, it seems, single individuals comprised of multiple living, breathing, moving parts The we learn about this fascinating microscopic community, the clearer it becomes that our fate is inextricably tied to theirs, making it essential that we learn about where our microbes come from, what they do, and why we literally cant live without them.Meet Your MicrobiomeThe microbiome refers to all of the organisms that live in or on your body all of the bacteria, viruses, fungi, protozoa, and helminths worms, for those of us who have them , as well as all of their genes A staggering hundred trillion microbes that include thousands of different species inhabit your nooks and crannieswith than a billion bacteria in just one drop of fluid in your colon alone.Your unique microbial footprint develops over your lifetime, and it reflects everything about you your parents health, how and where you were born, what youve eaten including whether your first sips were breast milk or formula , where youve lived, your occupation, personal hygiene, past infections, exposure to chemicals and toxins, medications, hormone levels, and even your emotions stress can have a profound effect on the microbiome The end result is a microbial mix so distinctive from person to person that yours is a accurate identifier of you than your own DNA.Weve known about the microbiome since the 1600s, when Antoni van Leeuwenhoek first looked at his own dental plaque under the microscope and described little living animalcules, very prettily a moving But its taken us a few centuries to figure out that these fellow travelers might actually be helping rather than hindering us, with a specific purpose thats very much aligned with our own survival The overwhelming majority of our microbes arent germs that cause disease Quite the contrarytheyre an essential part of our ecosystem and play a vital role in keeping us healthy.How do we get from germ free fetus to living, breathing petri dish, colonized with trillions of bacteria Lets start at the cradle and work our way toward the grave, to find out exactly how our microbiome evolves and the crucial role it plays at every stage in our development.PregnancyLong before we enter the world, our mothers microbiome starts to prepare for our arrival One of the most dramatic changes happens in her vagina During pregnancy, cells in the vaginal lining ramp up production of a carbohydrate called glycogen, sending glycogen loving Lactobacillus bacteria into a feeding frenzy and increasing their numbers Lactobacilli convert lactose and other sugars to lactic acid, creating an acidic, unfriendly environment that helps to protect the growing fetus from potential invaders.Bacteria dont just protect us from undesirable germs that can enter via the vagina they also nurture us In the third trimester of pregnancy, Proteobacteria and Actinobacteria species increase in number and cause a corresponding rise in the mothers blood sugar and weight gain in her breasts, with the specific goal of ensuring adequate growth and breast milk for the baby Transplanting gut bacteria from late trimester pregnant women into nonpregnant mice produces identical changes in the miceconfirming that the transformation is indeed mediated by gut bacteria, not hormones.In addition to our founding species of bacteria, we also receive protective antibodies from our mother through the placenta Armed with these antibodies and our own few but plucky microbial soldiers, were ready to make our entrance into the world But exactly how we enter isnt just a matter of convenience it has significant microbial repercussions that continue to affect our health well into adulthood.BirthDuring a normal delivery, the babys head turns to face the mothers rectum as it crowns and exits the birth canal This turning brings the babys nose and mouth into direct contact with her vaginal and rectal contents What better way to get inoculated with a good dose of bacteria than to come face to tush with the source A study published in Proceedings of the National Academy of Sciences showed that babies born vaginally are colonized with Lactobacillus species and other good bacteria, while babies born by C section tend to have common hospital bad bacteria like Staphylococcus that are associated with illness and infection.This brief act of swallowing a mouthful of our mothers microbes as we enter the world confers unbelievably important benefits It turns out that exposure to bacteria is a critical early step in the development of our immune system C sections bypass this crucial event and are associated with higher rates of asthma, allergies, obesity, type 1 diabetes, and other autoimmune conditions Ill explain the importance of early microbial exposure in detail in Chapter 3, and the modern plagues that are a result of not having enough of it.Breast feedingHuman milk oligosaccharides HMOs are the third most common ingredient in breast milk, despite the fact that theyre completely indigestible by infants HMOs are indigestible because theyre not there to feed the baby Theyre there to feed the babys bacteriaspecifically, Bifidobacterium, present in high numbers in breast fed infants Bifidobacterium repels Staphylococcus and other harmful microbes on the mothers nipple, so its an essential part of the babys microbial arsenal While Bifidobacterium gorges on HMOs, Lactobacillus in the newborns gut breaks down sugars and the other digestible components of breast milkan incredibly well designed example of the symbiotic relationship between humans and microbes.Breast fed babies in the United States have an astounding 20 percent higher survival rate than their formula fed peers Ill discuss the worrisome trend of formula over breast milk in Chapter 7, where we examine the microbial implications of some of our modern practices.InfancyWhen we are babies, everything eventually ends up in our mouth Its one of the ways we interact with our environment Its also one of the ways our environment interacts with our microbiome, allowing bacteria from our home, our siblings, and even our pets to gain access to our gut and help train our immune system to distinguish friend from foe Factors like family size, early nutrition, and the quality of our water supply have a profound effect on our blossoming microbiome.Not surprisingly, as infants our microbiome most closely resembles that of other household members, especially our mothers But its a constantly changing and evolving mix, with lots of species diversity, and events like a fever, a dietary change, or a course of antibiotics can have a major ripple effect Within a few weeks after birth, bacteria in various parts of our body start to branch out and specialize, and within a few months, the number of species starts to rise, increasing from about a hundred in infancy to a thousand or by adulthood.Childhood to AdulthoodBy age three our microbiome is almost fully formed and is very similar to that of an adult, although major changes like puberty, the onset of menstruation, pregnancy, and menopause are associated with huge microbial shifts Some of the physical changes associated with puberty, such as increased oil production that can lead to acne, or pungent body odor under the arms and in the groin, are actually the result of changes in bacteria, as different species become or less dominant.By the time we become senior citizens, weve lost much of our bacterial diversity, and our microbiome starts to resemble that of others in our peer group Shifts within various microbial populations continue to occur, but as we get older, our microbiome becomes stable, tending to revert to its previously established baseline after events like an infection or a course of antibiotics.RenewalWe start out in the womb with no microbes at all, and we eventually acquire trillions What happens to all of those microbes when we die Interestingly, the microbes arent recycled They die with us, and each subsequent generation goes through its own cycle of microbial rebirth, starting from scratch and working its way up to an incredibly well stocked microbial kingdom, well adapted lets hope to the requirements of that generation.Diversity of species is a vital part of maintaining a balanced ecosystem in the outside world, and its also crucial in the microscopic world inside us Unfortunately, modern life has made microbial depletion part of our legacy, with decreased diversity in each successive generation as a result of medications, our overprocessed diet, and our super sanitized lifestyle Americans today have only about two thirds as many bacterial species as native tribesmen in the who havent been exposed to antibiotics As well learn in the second part of this book, restoring those lost microbes takes real commitment.While there is no perfect microbiome, some are clearly healthier than others, notwithstanding the incredible variation from one to the other The Human Microbiome Project and other research efforts like it seek to establish what the normal human microbiome looks like todayan important endeavor, considering the rate at which our microbial landscape is changing Companies like uBiome allow the citizen scientist to catalogue his or her own microscopic habitat, compare it to others, and reassess it as diet and habits change.The human microbiome may well be the next big frontier in medicine, providing answers to why we get sick and novel solutions for how to heal ourselves In the next chapter well learn about what our gut bacteria actually dobesides make gasand why theyre so essential to our health and well being.CHAPTER 2 THINK OF YOUR BODY as a factory Organs like your lungs, kidneys, and liver represent the machinery that keeps production moving extracting oxygen, filtering blood, removing toxins, synthesizing hormones, and performing all of the other complicated tasks that keep us alive Some of the tasks are automated, but most of these assembly lines require constant monitoring, maintenance, and adjustment.We house the machinery, but who operates it How does a complex process like, for example, digestion, actually happen Who helps break down the food and determines what gets absorbed versus what gets excreted How do we distinguish between real infection and colonization with harmless bacteria Who tells our immune system when to rally the troops and when to ignore benign interlopers that pose no threat Our microbes do Weve evolved over millions of years to host an incredible army of worker bee microbes that are gainfully employed assisting in all of our bodily functions They produce substances our bodies require but cant make They fight most of our battles for us They even turn our genes on and off, activating those we need and dismantling those we dont In exchange, we provide room and board.Since were their host and they rely on us for their survival, most of our microbes are invested in our well being, although under certain circumstances they can turn on us and cause bad things to happen such as infection or even cancer We can categorize our microscopic roommates into three main groups Commensal bacteria that cohabit peacefully with usSymbiotic organisms sometimes called mutualists that help keep us healthyPathogens also known as opportunistic flora that can do us harmIts a Jungle in ThereMost human bacteria fall within four general phyla, or families Actinobacteria, Firmicutes, Proteobacteria, and Bacteroideteseach one consisting of many different species Different parts of the body have different microbial communities based on variations in things like oxygen content, moisture, and blood flow Anaerobic species that dont require oxygen predominate in the gut Staphylococci thrive on the skin and the same Streptococci used to make Swiss cheese inhabit the mouth and upper airway There are pathogenic i.e., harmful forms of all of these bacteria, but the ones that reside with us on a daily basis are mostly harmless, particularly when kept in check by adequate amounts of their symbiotic cousins.TABLE 21 Predominant Bacteria Present in HumansAn enterotype is a classification based on ecosystems in the gut, and a way to stratify people based on the relative abundance of different species In 2011, researcher Peer Bork described three specific enterotypes in humans high levels of Bacteroides characterize type 1 type 2 has few Bacteroides and lots of Prevotella and type 3 has high levels of Ruminococcus Different enterotypes dont seem to be influenced by age, gender, or nationality, but they are profoundly affected by long term diet A Western diet high in protein and animal fat is associated with Bacteroides type 1 , while Prevotella species type 2 dominate in those who consume carbohydrates, especially fiber Different enterotypes are associated with predisposition to particular disease states, such as obesity and inflammation, confirming that what you eat is a powerful influencer of your overall health In the future, we may be able to prescribe enterotype specific diets and probiotics designed for maximal efficacy based on the abundance of various species.What Do Gut Bacteria Do Symbiotic organismsthe quintessential good bacteriahave lots of important jobs They help us digest food, maintain the integrity of our gut lining part of the epithelial barrier that keeps bowel contents separate from the rest of the body , crowd out harmful bacteria, and train our immune system to distinguish between friend and foe They also convert sugars into short chain fatty acids SCFAs that intestinal cells use for energy, and they synthesize many of the enzymes, vitamins, and hormones that we cant make on our own Food cant be properly broken down and its constituent parts cant be fully absorbed without these essential gut bacteria, which means that even if youre eating a super healthy diet, if you dont have enough of them, you may not be able to absorb and assimilate all of the vitamins and nutrients in your food.Most of the bacteria in your gut are anaerobic, meaning that they thrive in areas with little or no oxygen As you travel from the top to the bottom of the intestines, the amount of bacteria increases, so the stomach and small intestine have a lot less than the colon Some bacterial species set up shop in the intestinal lining, while others just pass through, sometimes reproducing while in transit before being excreted in the stool.TABLE 22 What Do Your Gut Bacteria Do Convert sugars to short chain fatty acids SCFAs for energyCrowd out pathogensDigest foodHelp your body absorb nutrients such as calcium and ironKeep pH balancedMaintain the integrity of the gut liningMetabolize drugsModulate genesNeutralize cancer causing compoundsProduce digestive enzymesSynthesize B complex vitamins thiamine, folate, pyridoxine Synthesize fat soluble vitamins vitamin K Synthesize hormonesTrain the immune system to distinguish friend from foeImmune RegulationDigestion isnt the only process that relies on the presence of gut bacteria Exposure to lots of different microbesboth good and badis essential for priming and training your immune system, so that later on its able to distinguish between harmless organisms that it should ignore and dangerous pathogens that it needs to respond to In Chapter 7 well find out what happens when we super sanitize our environment and miss out on that crucial early microbial exposure.Gene ModulationWe have about twenty three thousand human genes and eight million microbial ones Results from large scale human microbiome studies suggest that genes from gut bacteria play an important role They provide instructions for essential functions like carbohydrate metabolism and enzymatic detoxificationinstructions that are missing from our own human genome Bacteria also help determine which diseases are expressed, turning various human genes on and off in response to the bodys internal milieu, which can influence whether or not a disease that youre genetically predisposed to actually develops Modulation of our genes by bacteria may explain why inherited diseases dont always afflict family members equallyeven in identical twins, who have the same genes but different microbes.Youre Only as Healthy as Your Gut BacteriaEver notice how some people never get sick when everyone else has the flu They were probably exposed to the same virulent virus, but because they have a healthier microbiome populated with essential microbes, theyre able to crowd out the pathogens and stay healthy Antibiotics can actually make you susceptible to infection because they deplete essential bacterial species that can fight off viruses and dangerous bacteria A recent study injected a bacterial protein into mice suffering from Rotavirusa diarrheal illness that kills half a million children each yearand successfully halted the infection The same protein also showed efficacy against other viruses, including influenza, demonstrating the important role bacteria play in protecting against viral infection.Microbial health is one of the factors that determines who survives potentially deadly viruses The very young, whose microbiome is still developing, and the very old, who have fewer microbial species and less diversity, tend to be the most vulnerable Overzealous antibiotic use also puts you at risk by stripping out the good microbes along with the bad Of course, additional variables like coexisting medical problems and how well nourished you are play a role, too, but those factors are also tied to the health of your microbiome, so having enough good bacteria looms large as a way to protect yourself from acute as well as chronic illness.Allison is a patient I see for chronic constipation and bloating While her gastrointestinal GI symptoms have improved a lot with adding fiber to her diet, she continues to be plagued by chronic sinus infections Every time I see her shes either on an antibiotic or just finished taking one The antibiotics she takes, the sinus infections she seems to get Well take an in depth look at how heavy antibiotic use can compromise your microbiome in Chapter 4, Pharmageddon and the Antibiotic Paradox.Recognizing that infection is frequently a result of bacterial imbalance as opposed to infestation with any one particular bad bug helps us to be judicious in our approach to treatment We all have organisms within us whose growth, if left unchecked, can reach problematic proportions The solution isnt to embark on a search and destroy antimicrobial mission, devastating our essential bacteria along with the bad guys, but rather to repopulate and rebalance, adding good bacteria through dietary changes, microbe friendly practices, prebiotic foods, and a well chosen probiotic supplement My Live Dirty, Eat Clean Plan will tell you exactly how to accomplish that, improving any health issues you have now and helping to safeguard against future illness.The Nose KnowsOur different anatomical microbial communities have their own distinctive signature odors, based on what the various bacteria consume and the waste products they make Morning breath is a great example of how shifting microbial populations are associated with a distinct change in odor Most of us sleep with our mouth closed, breathing mostly through our nose That leads to lower levels of oxygen in the mouth and an overnight increase in anaerobic bacteria, whose by products give our breath a sour smell People who have inflammation in their colon from Crohns disease, ulcerative colitis, or acute infection also have significant shifts in the composition of their gut bacteriachanges that I can smell even before seeing when I insert the colonoscope to examine the colon.Most animals can detect variations in the microbiome They sniff each other for recognition, to tell whether females are in heat, and to detect fear in their prey If we deigned to take a whiff, wed notice lots of identifying features, toowho has smelly feet, eats a lot of meat, or is stressed outits all reflected in our microbiome I smell my daughter all the time much to her dismay , and as she approaches puberty, Im noticing lots of changes But mostly I just know what she smells like, the specific aroma that is unique to her and that I like to think I could recognize anywhere.Growing a Good Gut GardenAs Ive mentioned, theres incredible microbial variation from person to person, which makes it difficult to define exactly what the ideal microbiome looks or smells like Our health depends on having the right balance, without any one species becoming unnaturally dominant or submissive, and with essential bacteria sufficiently represented.Gut bacteria are influenced by all the factors Ive already mentioned, like whether you were breast fed, your age, your gender, your occupation, and where you live But what you eat is emerging as the most influential factor, since bacteria follow the food So rather than focusing on what you should be eating to lose weight, or to lower your cholesterol, or to avoid diabetes, you should really be asking yourself what you should be eating to grow a good gut garden, because disease is rare when gut bacteria are balanced, bountiful, and diverse.The other essential step is recognizing what threatens your gut gardens growth Being aware of the interlopers and inclement conditions that will reduce your victory garden to an overgrown or blighted plot is key In the next part of this book well explore in detail how the microbiome gets messed up, and what you can do to preserve yours.part 2CHAPTER 3 MANY OF US were brought up to believe that its better to be clean than dirty But evidence is mounting to show that if you start from that premise, you will arrive at the wrong destination as far as human health is concerned The microbial communities established in our bodies at birth, during infancy, and in early childhood mold our health as we grow and help determine whether or not we develop illness The unwilding of our internal landscape has created health challenges we never anticipated and led to the emergence of a new breed of disease.Microbes and Our Modern PlaguesIn 1932, gastroenterologist Burrill Crohn, MD, and his colleagues at Mount Sinai Hospital published a paper describing fourteen patients who had peculiar findings in the small intestine at surgery that were unlike anything that had previously been seen The abnormalities were in the end of the small intestinean area known as the ileumso they called the new disease terminal ileitis, although it would eventually come to be known as Crohns disease.Inflammatory bowel diseases IBD , such as Crohns disease and its sister condition, ulcerative colitis, are examples of autoimmune diseases They represent a new breed of malady, sometimes referred to as modern plagues, which has emerged in the last century and includes conditions such as Hashimotos thyroiditis, type 1 diabetes, lupus, multiple sclerosis MS , rheumatoid arthritis, and eczema Their hallmark, regardless of what organ they affect, is that the immune system wages war against the bodys own healthy tissues, leading to chronic inflammation.There are almost a hundred different types of autoimmune diseases Chances are you or someone in your family suffers from one, since they affect about fifty million people in the United States alone Different autoimmune diseases frequently affect the same person, suggesting a common cause with varied manifestations rather than multiple distinct ailments The million dollar question is whether that common cause is an abnormal immune system overreacting to normal stimuli in the environment, or a normal immune system responding to an abnormal trigger.TABLE 31 Common Autoimmune DiseasesAddisons diseaseAlopecia areataAnkylosing spondylitisCeliac diseaseCrohns diseaseDermatomyositisDiabetes type 1 EczemaEosinophilic esophagitisGraves diseaseHashimotos thyroiditisIdiopathic thrombocytopenic purpura ITP Interstitial cystitisJuvenile arthritisLupus SLE Multiple sclerosis MS Myasthenia gravisPolymyositisPrimary biliary cirrhosisPrimary sclerosing cholangitisPsoriasisPsoriatic arthritisRaynauds phenomenonRheumatoid arthritisSarcoidosisSclerodermaSjgrens syndromeUlcerative colitisUrticariaVasculitisVitiligoUnderstanding the relationship between our immune system, our microbial environment, and our genes is critical to figuring out why people suffer from these diseases and how to heal them Since most of our germs and than half of our immune system are located in our gut, taking a closer look at Crohns disease in the context of the microbiome may yield some valuable answers.Guts, Germs, and GenesDr Crohn was convinced that this new disease, which caused inflammation, weight loss, and diarrhea, was the result of a bacterial infection, although not everyone shared his view At that time, Crohns disease was most often diagnosed in people of Jewish heritage, and the prevailing wisdom was that Crohns was a genetic rather than an infectious disease The bacterium in question was Mycobacterium avium subspecies paratuberculosis MAP It was known to infect the same area of the ileum in cows and other ruminants, causing a Crohns like wasting diarrheal illness in these animals called Johnes disease after the German veterinarian who described it in 1905.In addition to the similarities in location and symptoms, there were two other compelling pieces of evidence in support of Dr Crohns theory that bacterial infection caused Crohns disease The first was that MAP had been isolated from the intestines of Crohns patients at much higher rates than in the general public The second was that because of its ability to survive pasteurization, MAP was detectable in various milk products, providing a plausible way for it to get from cows to humans But what kept this from all fitting together nicely was that not everyone who had Crohns disease had MAP In fact, most Crohns sufferers tested negative for MAP So, after additional studies were unable to prove clear cause and effect, the idea that Crohns was the result of a bacterial infection was mostly abandoned.Almost a century later, we still dont know what causes autoimmune illnesses such as Crohns, although theres been lots of speculationfrom infections like measles, E coli, and enterovirus to lifestyle factors like smoking and stress to common and seemingly benign practices like the use of toothpaste and refrigeration In keeping with Dr Crohns initial theory, emerging evidence suggests that bacteria do indeed play a major role, but it may be their absence rather than their presence that leads to the diagnosis.The Hygiene HypothesisIn the late 1950s, Professor David Strachan, a lecturer at the London School of Hygiene and Tropical Medicine, embarked on an epidemiological study of hay fever and eczema in British children These diseases had been steadily increasing since the turn of the century when large populations left the farm for the factory The study followed seventeen thousand children from birth to adulthood, and the results revealed a startling and unexpected association both conditions were far less common in large families with lots of early childhood infections from exposure to siblings The highest rates of disease occurred in smaller family size with fewer runny nosed microbial donors and in affluent households with loftier standards of personal hygiene This finding was counter to everything we thought we knew about germs Could exposure to germs really be better for us And could living a cleaner lifestyle be making us sicker Strachans initial paper, titled Hay Fever, Hygiene and Household Size, was published in the British Medical Journal in 1989 and laid the foundation for the hygiene hypothesis, which challenged the idea of germs as something to be avoided and posited the importance of early microbial exposure for preventing disease later in life In 2003 Graham Rook, MD, emeritus professor of medical microbiology and immunology at University College London, expanded on this concept with his Old Friends hypothesis, suggesting that a lack of exposure to ancient organisms like parasites that coevolved with our ancestors, not just the absence of relatively new germs like influenza, was responsible for the emergence of these modern plagues.If we look at a map of the world today, one of the striking observations is that illnesses like Crohns disease are common in developed countries and rare in less developed ones The hygiene hypothesis accounts for this uneven distribution by suggesting that less childhood exposure to bacteria and parasites in affluent societies like the United States and Europe actually increases susceptibility to disease by suppressing the natural development of the immune system.Praise for The Microbiome SolutionGastroenterologist Chutkan Gutbliss makes a strongly argued proposal that people should live dirty and eat clean Athoughtful approach to health and wellness thats well worth the time of readers Publishers WeeklyWe are truly in the middle of an epidemicthrough our diet and our lifestyle we are unwittingly destroying the good bacteria in our bodies, the crucial allies we need to arm us against disease In this life changing book, Robynne Chutkan gives you simple, foolproof guidance to repair this vital ecosystem and bring you optimal health every day Read this important book and discover the small changes that can make a huge impact Frank Lipman, M.D., founder of Eleven Eleven Wellness Center and author ofthe New York Times bestseller The New Health Rules The exciting research on the microbiome has the promise to help many take charge of their health and reverse chronic ailments But what is so groundbreaking about this book is that it shows you how to put these scientific breakthroughs into practice, step by step With Dr Robynne Chutkan as your guide, youll understand how overuse of antibiotics, the standard Western diet and a super clean lifestyle starve your microbiome, and learn the essential tools to attain sustainable good health This book is empowering, and indispensable for anyone trying to get or stay well Terry Wahls, M.D., author of The Wahls Protocol I whole heartedly agree with Dr Chutkan that there is a rising epidemic of vague symptoms often attributable to a damaged microbiome, from bloating and food intolerances to brain fog and weight loss resistance Her mantra Live dirty, eat clean is a scientifically sound solution Try her simple program and get ready to feel the changes immediately Its the proven way to build up our good bugs and keep your body strong and vibrant, ready to fight illness and disease Its something we can all do, each and every day You will truly transform your health Sara Gottfried, M.D., author of the New York Times bestsellers The Hormone Cure and The Hormone Reset Diet The Microbiome Solution is the medicine we all need to truly flourish Christiane Northrup, M.D., author of the New York Times bestsellers Goddesses Never Age, Women s Bodies, Women s Wisdom, and The Wisdom of MenopauseWe live in symbiosis with trillions of bacteria that play a crucial role in determining our health and vitality The Microbiome Solution is an eye opening account of how supersanitation, antibiotic overuse and the Western diet collaborate to promote chronic disease by disrupting the gut microbiomes ecological harmony and balance Dr Chutkan, a leading integrative gastroenterologist, presents a trailblazing program to heal your body from the inside out by getting dirty and eating clean Read this marvelous book and transform your health..one gut microbe at a time Gerard E Mullin MD, Associate Professor of Medicine The Johns Hopkins University School of Medicine and Author of The Gut Balance RevolutionPraise for Gutbliss I read it cover to cover Natalie Morales, Today ShowDr Chutkan candidly explores how digestive snafus can wreak havoc with professional, social and sexual relationships, using anecdotes about patients who suffered terribly before finding relief by changing their habits, conquering crummy diets and identifying medical conditions that exacerbated their misery Her plan may be worth tryingeven if it means giving up some bubbly The Wall Street JournalPacked with no nonsense explanations, real life patient stories, and remedies, this guide will empower women to recognize their particular digestive health issues and work proactively with their medical professionals to prevent, treat, and solve them Publishers Weekly Gutbliss is loaded with helpful, leading edge information that all women need to know for optimal bowel health I highly recommend this book Christiane Northrup, M.D., author of THE WISDOM OF MENOPAUSEDr Chutkan blasts away the bloat as she tastefully explains the guts of our problems Mehmet Oz, M.D.Millions of Americans suffer needlessly from digestive problems Gut issues are at the core of many health problems including autoimmune disease and even obesity and diabetes Dr Robynne Chutkan maps out a clear strategy for gut health and restoring optimal health If you have digestive problems, look no further, and buy this book Mark Hyman, M.D., author of THE BLOOD SUGAR SOLUTIONIf youre tired of dreaded bloat or muffintop, Dr Chutkan offers a novel prescription for making your gut work for you, not against youand her 10 day plan is scientifically robust yet transformative Get the book, and give her 10 days Youll discover the small hinge that swings big doors Sara Gottfried, M.D., author of THE HORMONE CURE From the Hardcover edition. The Microbiome Solution Gutbliss The is an eye opening account of how supersanitation, antibiotic overuse and the Western diet collaborate to promote chronic disease by disrupting gut microbiome s ecological harmony balance A Radical New Way Heal Your recipes provided in accompanying PDF Audible version highly useful for me I ve never found so many good recipes, one place, that can tolerate, as have Finally, not least importantly, book ends with pages solution mostly dishes will feed suppress bad bacteria live within you food stomach, skin, soul offers a overview, nourishing questions your doctor, preventative recovery health tips, next frontier severely troubled stool transplant With Dr Robynne Chutkan Oct , FInd out proven solutions IBS, candida, colitis Chutkan MD Aug This first provide practical, effective plan replenishing optimizing vital ecosystem our Digestive Center Wellness Healing Body From Jan book, Solution, provides excellent chapter on fecal microbiota transplants FMTs It even includes instructions do it yourself, were choose route While most people are candidates transplant, be life saving measure extreme cases Kale Chocolate Have heard term Up until about year ago, hadn t really either But when Chutkan, author close friend Cape Town to Kruger: Backpacker Adventures in South Africa and Swaziland (Round the World Travel Book 1) refers all bacteria, viruses, fungi or body over trillion microbes, plus their genes More than billion justHome bestselling Gutbliss, Bloat Cure years clinical experience, she unique, innovative, easy follow approach digestive transform Dr Book Appointment Chevy gastroenterology specialist Chase, She graduated from Columbia University College Of Physicians Surgeons specializes Gastroenterology Chase Sharecare expert board certified Gastroenterologist founder medical director GutBiome Institute, integrative practice nutritional optimization, exercise stress reduction part therapeutic diseases, focusing Home Facebook Maryland K likes gastroenterologist, Gutbliss Revitalize Why Is Feb Integrative gastroenterologist breaks down what need know microbiome, vast collection microbes body, optimize Books blasts away bloat tastefully explains problems Mehmet Oz, maps clear strategy restoring optimal Reviews best gastroenterologists areas expertise, including Hemorrhoids, Constipation, Colonoscopy See patient ratings reviews, share experiences, search doctors at Vitals Eating Right Rosacea Answers Eating Diet play big role managing rosacea Get skin care tips patients Live Dirty, Eat Clean Everything Our bodies comprised ten cells outnumber human factor Robynne HuffPost was host moderator NIH sponsored series Clinical Roundtable Bench Bedside Series which covered wide range topics shares Gut Secrets Never Chutkhan, center women, talks enzymes boosting immune system during these winter months Interview Author Solution Damage we call dysbiosis, root cause broad diseases Not just gastrointestinal disorders like Crohn s, ulcerative colitis, irritable bowel syndrome IBS but autoimmune thyroid disorders, multiple sclerosis MS type diabetes Wiki Bio Everipedia wiki American known being top physicians her field who has made several local national television appearances around United States What Learned Washingtonian Patricia Wood connect parents level truly product walking shoes Portrait Stephen Voss What Five moms thoughts parenting don torture myself second guess As long everyone alive breathing, There no question number eat grow garden plant fiber, there debate Gutbliss Day Plan Ban Bloat, Flush Toxins, Dump Baggage FREE shipping qualifying renowned physician complete day tune up important revelations Many called cures women bloating indigestion Here You Don Need Shower Soap Health Most us think germs dirty dangerous probably heard, re crawling bugs, crucial digestion, health, immunity Oz Explains Total Rapid Weight Loss Plan details Plan, protein packed rev Quick Cures Tummy Troubles Signs Serious Than Common Cold Doctors explain tell if common cold something Rhonda Patrick On Longevity, Epigenetics We actually verge serious resistance cropping up, scary absolutely terrifying episode geeky deep dive into hardcore science behind everything telomeres mechanisms Camp Plant Stock Based Weekend Engine Events Williams served numerous committees boards level, Society Nuclear Cardiology ASNC Heart Association AHA Medical AMA ACC Certifying Board Cardiology, Cardiac Computed Tomography, Gastrointestinal Fistula Causes, Symptoms, Diagnosis fistula GIF abnormal tract causes gastric fluids seep through lining stomach intestines Foods That Contain Natural Enzymes organs work together make systemThese take liquids break them simpler forms, such proteins, carbs, fats vitamins metabolism sugar carb addictions aging longevity primacy maintaining Cardiovascular The Microbiome Solution: A Radical New Way to Heal Your Body from the Inside Out
- The Microbiome Solution: A Radical New Way to Heal Your Body from the Inside Out
- Format Kindle
- 304 pages
- Dr Robynne Chutkan M.D.
- 15 May 2016 Dr Robynne Chutkan M.D.